SYNTHESIS OF CHIRALLY PURE 2,5-DISUBSTITUTED DIKETOPIPERAZINES DERIVED FROM TRISUBSTITUTED PHENYLALANINES

Authors
DANTHI SN HILL RA
Citation
Sn. Danthi et Ra. Hill, SYNTHESIS OF CHIRALLY PURE 2,5-DISUBSTITUTED DIKETOPIPERAZINES DERIVED FROM TRISUBSTITUTED PHENYLALANINES, Journal of heterocyclic chemistry, 34(3), 1997, pp. 835-844
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
3
Year of publication
1997
Pages
835 - 844
Database
ISI
SICI code
0022-152X(1997)34:3<835:SOCP2D>2.0.ZU;2-J
Abstract
Some new chirally pure 2,5-substituted diketopiperazines were synthesi zed starting from 2-methoxybenzyl alcohol. This multistep synthesis pr oceeds through the enzymatic synthesis of chirally pure amino acids, p rotection and dipeptide coupling, cyclization of dipeptide ester forma tes, and nitration of the resulting diketopiperazines.