COMPOUNDS BASED ON MESO-TRI(4-PYRIDYL)-P-ACRYLAMIDOPHENYLPORPHYRIN ABLE TO INTERACT WITH DNA

A new type of porphyrinyl-nucleoside was synthesized by the Heck react ion of meso-tri(4-pyridyl)-p-acrylamidophenylporphyrin with (+)5-iodo- 2'-deoxyuridine. The porphyrin used in this reaction was also applied in obtaining a water soluble porphyrin polymer and a copolymer with ac rylamide. The porphyrinyl-nucleoside and the polymer and copolymer wer e investigated for their interaction with ds DNA, oligonucleotides and oligonucleotide duplexes. The extend of the red-shift of the Soret ba nd of porphyrins and the slowing of the mobolity of DNA during electro phoresis of the interacting systems suggested that intercalation of ca tionic porphyrin units into ds DNA cannot be solely responsible for th e observed phenomena.