We present the results of a high angular resolution, multi-transition analy
sis of the molecular gas in M82. The analysis is based on the two lowest tr
ansitions of (CO)-C-12 and the ground transition of the rare isotopes (CO)-
C-13 and (CO)-O-18 measured with the PdBI, the BIMA array and the IRAM 30 m
telescope. In order to address the question of how the intrinsic molecular
cloud properties are influenced by massive star formation we have carried
out radiative transfer calculations based on the observed CO line ratios. T
he calculations suggest that the kinetic temperature of the molecular gas i
s high in regions with strong star formation and drops towards the outer mo
lecular lobes with less ongoing star formation. The location of the highest
kinetic temperature is coincident with that of the mid infrared (MTR) peak
s which trace emission from hot dust. The hot gas is associated with low Hz
densities while the cold gas in the outer molecular lobes has high Ha dens
ities. We find that CO intensities do not trace Ha column densities well. M
ost of the molecular gar; is distributed in a double-lobed distribution whi
ch surrounds the starburst. A detailed analysis of the conversion factor fr
om CO intensity to Ha column density shows that X-CO depends on the excitat
ion conditions. We find X-CO similar to T-kin(-1) n(H-2)(1/2), as expected
for virialized clouds.