Immobilization of bisphosphonates on surface modified titanium

The efficiency of surface modifications on the immobilization of bisphospho nates on titanium was investigated with Ca-ion implantation and thin hydrox yapatite coatings. The ALP activity of osteoblastic cells and the inhibitor y effects on the initial adherence QI P. gingivalis were also evaluated usi ng bisphosphonate-immobilized titanium. X-ray photoelectron spectroscopy an alysis suggested that titanium surfaces modified with Ca-ion implantation a nd thin hydroxyapatite coatings caused the immobilization of bisphosphonate on titanium plates. The ALP activity of osteoblastic cells cultured on pla tes immobilized with bisphosphonate was almost the same as that of cells cu ltured on titanium plates, indicating that the bisphosphonate-immobilizatio n showed no toxic effect on osteoblastic cells, and that it provides a favo rable micro-environment with osteogenetic ability. Data of the adherence of oral bacteria showed that a bisphosphonate-immobilized titanium surface in hibited the initial adherence of P. gingivalis. These results indicate that the immobilization of bisphosphonates on titanium modified with Ca-ion imp lantation and thin hydroxyapatite coatings are useful for dental implants. (C) 2001 Elsevier Science Ltd. All rights reserved.