beta-D-glycosylamidines: Potent, selective, and easily accessible beta-glycosidase inhibitors

Authors
Guo, WF Hiratake, J Ogawa, K Yamamoto, M Ma, SJ Sakata, K
Citation
Wf. Guo et al., beta-D-glycosylamidines: Potent, selective, and easily accessible beta-glycosidase inhibitors, BIOORG MED, 11(4), 2001, pp. 467-470
Citations number
33
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
467 - 470
Database
ISI
SICI code
0960-894X(20010226)11:4<467:BPSAEA>2.0.ZU;2-V
Abstract
beta -D-Glycosylamidines, in which a glycon is connected via an N-glycoside linkage with a substituted amidine (aglycon), were synthesized in two step s from the corresponding sugars and served as stable and potent beta -glycd sidase inhibitors with high selectivity according to the glycon- and alpha, beta -specificities of the enzymes. (C) 2001 Elsevier Science Ltd. All rig hts reserved.