Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines

Authors
Jiang, B Xiong, XN Yang, CG
Citation
B. Jiang et al., Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines, BIOORG MED, 11(4), 2001, pp. 475-477
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
475 - 477
Database
ISI
SICI code
0960-894X(20010226)11:4<475:SAAEON>2.0.ZU;2-F
Abstract
A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-t rifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P38 8 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3'-(N-tosyl-6 '-methoxyl-indolyl)] pyridine was identified as the most potent in this ser ies. (C) 2001 Elsevier Science Ltd. All rights reserved.