Synthesis and monoamine transporter affinity of 3 beta-(4-(2-pyrrolyl)phenyl)-8-azabicyclo[3.2.1]octanes and 3 beta-(5-indolyl)-8-azabicyclo[3.2.1]octanes

Authors
Davies, HML Ren, PD Kong, N Sexton, T Childers, SR
Citation
Hml. Davies et al., Synthesis and monoamine transporter affinity of 3 beta-(4-(2-pyrrolyl)phenyl)-8-azabicyclo[3.2.1]octanes and 3 beta-(5-indolyl)-8-azabicyclo[3.2.1]octanes, BIOORG MED, 11(4), 2001, pp. 487-489
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
487 - 489
Database
ISI
SICI code
0960-894X(20010226)11:4<487:SAMTAO>2.0.ZU;2-1
Abstract
3 beta-(5-Indolyl)-8-azabicyclo[3.2.1]octanes display potent binding affini ty for both the dopamine and serotonin transporters, while certain 3 beta-( 4-(2-pyrrolyl)phenyl)-8-azabicyclo[3.2.1]octanes selectively bind to the se rotonin transporter. (C) 2001 Elsevier Science Ltd. All rights reserved.