Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors

Authors
Ting, PC Lee, JF Anthes, JC Shih, NY Piwinski, JJ
Citation
Pc. Ting et al., Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors, BIOORG MED, 11(4), 2001, pp. 491-494
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
491 - 494
Database
ISI
SICI code
0960-894X(20010226)11:4<491:SOS4AD>2.0.ZU;2-R
Abstract
The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethy l)phenyl)methoxy]-3-(3,4-dichlorophenyl)4(Z)-(methoxyimino)pentyl-1-piperid ines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors. (C) 2001 Elsevier Science Ltd. All rights reser ved.