SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists

Authors
Chu, L Lo, JL Yang, YT Cheng, K Smith, RG Fisher, MH Wyvratt, MJ Goulet, MT
Citation
L. Chu et al., SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists, BIOORG MED, 11(4), 2001, pp. 515-517
Citations number
5
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
515 - 517
Database
ISI
SICI code
0960-894X(20010226)11:4<515:SSON52>2.0.ZU;2-J
Abstract
The discovery of the potency-enhancing effect of 5-substitutions on the nov el 2-arylindoles as nonpeptidyl GnRH receptor antagonists led to the identi fication of several analogues with high affinities on the GnRH receptor. Th e syntheses and SARs of these 5-substituted-2-arylindole analogues are repo rted. (C) 2001 Elsevier Science Ltd. All rights reserved.