Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. part 1: Contribution of the amino group and the uracil moiety upon the inhibition of MraY

Authors
Dini, C Drochon, N Feteanu, S Guillot, JC Peixoto, C Aszodi, J
Citation
C. Dini et al., Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. part 1: Contribution of the amino group and the uracil moiety upon the inhibition of MraY, BIOORG MED, 11(4), 2001, pp. 529-531
Citations number
6
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
529 - 531
Database
ISI
SICI code
0960-894X(20010226)11:4<529:SOAOTO>2.0.ZU;2-J
Abstract
The O-beta -D-ribofuranosyl nucleoside I is the minimal structural entity o f liposidomycins maintaining enzyme inhibitory activity. Modifications perf ormed on both the primary amine and the uracil moieties clearly demonstrate their major contribution to the inhibition of the bacterial translocase (M raY). (C) 2001 Elsevier Science Ltd. All rights reserved.