Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smoothmuscle cells

Authors
Ogita, H Isobe, Y Takaku, H Sekine, R Goto, Y Misawa, S Hayashi, H
Citation
H. Ogita et al., Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smoothmuscle cells, BIOORG MED, 11(4), 2001, pp. 549-551
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
549 - 551
Database
ISI
SICI code
0960-894X(20010226)11:4<549:SASROD>2.0.ZU;2-T
Abstract
A series of diarylamide derivatives were synthesized and evaluated for thei r inhibitory activities against human coronary artery smooth muscle cells ( SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was su perior to the lead compound, Tranilast, in terms of the potency of the acti vity and cell selectivity. (C) 2001 Elsevier Science Ltd. All rights reserv ed.