Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor
Rb. Westkaemper et al., Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor, BIOORG MED, 11(4), 2001, pp. 563-566
Comparison of the serotonin 5-HT2A receptor affinities of a parallel series
of structural analogues of the novel ligand 9-aminomethyl-9,10-dihydroanth
racene (AMDA) and a structurally similar prototypical tricyclic amine cypro
heptadine suggests that the two agents bind to the receptor in different fa
shions. Examination of ligand-receptor model complexes supports the experim
ental data and suggests a potential origin for the differences in binding m
odes. (C) 2001 Elsevier Science Led. All rights reserved.