Synthesis and antiviral activity of novel D- and L-2 '-azido-2 ',3 '-dideoxyribofuranosyl-4 '-thiopyrimidines and purines

Authors
Kim, HO Kim, YH Suh, H Jeong, LS
Citation
Ho. Kim et al., Synthesis and antiviral activity of novel D- and L-2 '-azido-2 ',3 '-dideoxyribofuranosyl-4 '-thiopyrimidines and purines, BIOORG MED, 11(4), 2001, pp. 599-603
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
599 - 603
Database
ISI
SICI code
0960-894X(20010226)11:4<599:SAAAON>2.0.ZU;2-G
Abstract
Novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and p urines have been synthesized starting from L-xylose and D-xylose, respectiv ely. Among synthesized compounds tested against several viruses such,as HIV -1, HSV-1, HSV-2, and HCMV, D-beta -N-6-methyladenine (ent-22a) and D-alpha -N-6-methyladenine (ent-22b) analogues were found to exhibit significant a nti-HCMV activity. (C) 2001 Elsevier Science Ltd. All rights reserved.