Relaxation induced by omeprazole does not change in diabetic rabbit corpuscavernosum

Objective To investigate the changes in relaxation responses to omeprazole in corpus cavernosal strips from rabbits with diabetes induced by alloxan. Materials and methods Diabetes was induced in 10 New Zealand white rabbits. After 8 weeks, the reactivity to electrical-field stimulation, carbachol a nd omeprazole of corporal strips from the penises of the diabetic animals a nd from 10 untreated controls was assessed in organ chambers. Results In the diabetic group, the relaxation responses of corpus cavernosa l strips to omeprazole were comparable with those of the control group, whe reas the relaxation responses to electrical field stimulation and carbachol were impaired. Conclusion The relaxant effect of omeprazole in corpus cavernosum was not a ffected by diabetes, in which neurogenic and endothelium-mediated relaxatio ns were impaired.