Mesenchymal stem cells: heading into the clinic

In recent Sears, there has been an increasing interest in non-hematopoietic pluripotent progenitor cells that are found in the bone marrow. Mesenchyma l stem cells (MSCs) are the first non-hematopoietic progenitors to be isola ted from the bone marrow and extensively characterized. In addition to thei r ability to support hematopoiesis, MSCs can differentiate into osteocytes, chondrocytes, tenocytes, adipocytes and smooth muscle cells, This article will review our current understanding of bone marrow stroma and MSCs and th eir potential therapeutic role in the setting of hematopoietic stem cell tr ansplantation.