Involvement of GABA(A) receptor in modulation of jaw muscle activity evoked by mustard oil application to the rat temporomandibular joint

Authors
Seo, K Hu, JW Cairns, BE Someya, G
Citation
K. Seo et al., Involvement of GABA(A) receptor in modulation of jaw muscle activity evoked by mustard oil application to the rat temporomandibular joint, BRAIN RES, 892(1), 2001, pp. 198-202
Citations number
39
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
892
Issue
1
Year of publication
2001
Pages
198 - 202
Database
ISI
SICI code
0006-8993(20010216)892:1<198:IOGRIM>2.0.ZU;2-F
Abstract
The effect of intrathecal administration of the GABA(A) receptor antagonist bicuculline methylbromide on jaw muscle electromyographic (EMG) activity e voked by mustard oil injection into the rat temporomandibular joint was stu died. Bicuculline given prior to mustard oil augmented the EMG activity evo ked by mustard oil, and 'rekindling' of EMG activity was induced by bicucul line given 30 min after mustard oil. These results suggest that central GAB A(A) receptors modulate reflex responses to noxious craniofacial stimuli. ( C) 2001 Elsevier Science B.V. All rights reserved.