Selective cancer cell killing by alpha-tocopheryl succinate

Authors
Neuzil, J Weber, T Gellert, N Weber, C
Citation
J. Neuzil et al., Selective cancer cell killing by alpha-tocopheryl succinate, BR J CANC, 84(1), 2001, pp. 87-89
Citations number
15
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
84
Issue
1
Year of publication
2001
Pages
87 - 89
Database
ISI
SICI code
0007-0920(20010105)84:1<87:SCCKBA>2.0.ZU;2-5
Abstract
We report that alpha -tocopheryl succinate, a vitamin E analogue with pro-a poptotic properties. selectively kills cells with a malignant or transforme d phenotype, i.e. multiple haematopoietic and carcinoma cell lines, while b eing non-toxic to normal, i.e. primary and nontransformed cells. These find ings strongly suggest a potential of this micronutrient in the therapy and/ or prevention of cancer without significant side-effects. (C) 2001 Cancer R esearch Campaign http://www.bjcancer.com.