BACKGROUND. Because primary carcinoma of the vagina comprises less than 2%
of all gynecologic malignancies, the reported experience in the treatment o
f large numbers of patients is available only from a few major centers and
most often encompasses a variety of differences in treatment selection and
technique. The objective of this study was to assess the long term results
of an interstitial iridium-192 afterloading implant technique using the Sye
d-Neblett dedicated vaginal plastic template.
METHODS. Patients who were treated from 1976 to 1997 were examined retrospe
ctively.
RESULTS. Seventy-one patients underwent interstitial implantation with (n =
61 patients) or without external beam radiotherapy. The median age was 59
years (range, 16-86 years). Patients were staged according to the internati
onal Federation of Gynecology and Obstetrics system and included Stage I (n
= 10 patients), Perez modification Stage IIA (n = 14 patients), Perez modi
fication Stage IIB (n = 25 patients), Stage III (n = 15 patients), and Stag
e nr (n = 7 patients). Each implant delivered an approximately 20-gray (Gy)
minimum tumor dose, with the total tumor dose reaching 80 Gy with integrat
ed external beam radiotherapy. Local control was achieved in 53 patients (7
5%). The median follow-up was 66 months (range, 15-163 months), and the 2-y
ear, 5-year, and 10-year actuarial disease free survival rates are 73%, 58%
, and 58%, respectively. By stage, 5-year disease free survival rates inclu
ded Stage I, 100% of patients; Stage IIA, 60% of patients; Stage IIB, 61% o
f patients; Stage III, 30% of patients; and Stage IV, 0% of patients. The f
actors disease stage and primary lesion size independently influenced the s
urvival rates. Significant complications occurred in 9 patients (13%) and i
ncluded necrosis (n = 4 patients), fistulae (n = 4 patients), and small bow
el obstruction (n = I patient).
CONCLUSIONS. Interstitial irradiation can effect local control in the major
ity of patients with primary carcinoma of the vagina with acceptable morbid
ity. Long term cure is demonstrable in patients with Stage I-III disease. (
C) 2001 American Cancer Society.