Chromosomal changes in a dedifferentiated chondrosarcoma: a case report and review of the literature

The chromosome abnormalities observed in a dedifferentiated chondrosarcoma are reported. A new molecular cytogenetic technique, spectral karyotyping, was used to identify and confirm structural rearrangements in this case. A review of the literature revealed that nine cases have been reported, in ei ght of which a complete description of the cytogenetic abnormalities was de scribed. Structural aberrations were most frequently reported in chromosome s 1 and 9, and chromosomes 7 and 19 were most frequently observed to be inv olved in numerical aberrations (trisomy and tetrasomy). In chondrosarcomas, structural aberrations in chromosomes 1 and 9 and trisomy or tetrasomy of chromosome 7 are among the more frequently observed aberrations. (C) 2001 E lsevier Science Inc. All rights reserved.