Waldenstrom macroglobulinemia with karyotypic aberrations involving both homologous 6q

Authors
Wong, KF So, CC
Citation
Kf. Wong et Cc. So, Waldenstrom macroglobulinemia with karyotypic aberrations involving both homologous 6q, CANC GENET, 124(2), 2001, pp. 137-139
Citations number
24
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
124
Issue
2
Year of publication
2001
Pages
137 - 139
Database
ISI
SICI code
0165-4608(20010115)124:2<137:WMWKAI>2.0.ZU;2-U
Abstract
An 84-year-old female presenting with proptosis and hyperviscosity syndrome was found to have Waldenstrom macroglobulinemia. Karyotypic analysis showe d structural chromosomal abnormalities involving both homologous chromosome s 6 with a deleted 6q at q21-q23 and a complex three-break rearrangement in the t(6;13;21)?(q21;q14;q11). A literature review suggests that deletions of chromosome 6 at 6q21 are associated with lymphoplasmacytoid differentiat ion and IgM production in B-cell chronic lymphoproliferative disorders. (C) 2001 Elsevier Science Inc. All rights reserved.