Structure determination of a novel ether-linkaged bisalkaloid acutiaporberine

A novel ether-linkaged bisalkaloid, acutiaporberine (I), was isolated from the root of Thalictrum acutifolium (Hand. Mazz,) Boivin, Its structure was determined by IR, MS, H-1 NMR, C-13 NMR, and 2D-NMR (H-1-H-1 COSY, C-13-H-1 COSY, NOESY, and HMBC), Ether-linkaged bisalkaloids, such as aporphine-ben zylisoguinoline type and bisbenzylisoquinoline type , have been found. Here in a novel type bisalkaloid composed of an aporphine and a protobebertine i s reported for the first time. Compound I can inhibit the growth of tumor c ells and apoptosis can be seen, However, compound I shows only slight toxic effects on normal soma cell lines.