Formation of 1,1 '-iminodicarboxylic acid derivatives, 2,6-diketo-piperazine and dibenzodiazocine-2,6-dione by variations of multicomponent reactions

The combination of multicomponent reactions (MCRs) of different amino acids , aldehydes, isocyanides and acids allows complex structures to be prepared in one-pot reactions. The synthesis of I,l'-iminodicarboxylic acid derivat ives 12 demonstrates the high selectivity of the Ugi Four Component Reactio n using two different aldehydes and two different isocyanides. The limitati ons of the MCRs are illustrated by the synthesis of a l,l'-iminodicarboxyli c acid derivative 6 from L-lysine. Furthermore, 2,6-diketopiperazines and d ibenzodiazocin-2,6-diones are synthesized via MCRs. (C) 2001 Published by E lsevier Science Ltd. All rights reserved.