Multimodal therapeutic concept in metastatic follicular thyroid cancer with hyperthyroidism

The coincidence of hyperthyroidism and thyroid carcinoma seldom occurs. Onl y few reports on functionally metastases of thyroid carcinoma have been pub lished. We report a 59-year-old man who underwent subtotal thyroidectomy fo r toxic nodular goiter. Histological examination revealed a follicular thyr oid carcinoma. After thyroidectomy and cervical lymphadenectomy the patient developed a strong hyperthyreosis. Scintigraphy showed strong radioiodine uptake in the sacrum. De-bulking resection of the metastasis followed by hi gh-dose radioiodine treatment was performed. After radioiodine therapy the patient became euthyroid. Treatment of hyperthyreosis in metastatic thyroid cancer requires a multimodal therapeutic concept.