Self-consistent field (SCF) modelling studies on a series of varying molecu
lar weight poly(lactic acid):poly(ethylene glycol) (PLA:PEC) particles (2:5
-15:5 kDa) that form micelles in aqueous solutions have been performed usin
g the formalism of Scheutjens and Fleer. The parameters were chosen to repr
esent a central core made from collapsed hydrophobic PLA blocks, and PEG bl
ocks, which form a corona layer extended into the solvent. These different
phases have been confirmed in H-1 and C-13 NMR experiments. From the analys
is of the relevant thermodynamic data of the series, particle radii and agg
regation numbers varying from 12.6 to 24.9 nm and from 17 to 280, respectiv
ely, have been predicted, which agree well with those obtained experimental
ly. The actual thickness of the PEG corona is fairly constant at approximat
ely 11 nm For the whole particle series indicating that the size of the PLA
core has little effect on the thickness of the PEG corona layer. Another i
mportant consideration of these particles is the PEG density at the surface
, which is related to the in vivo properties of these particles. The surfac
e area available to each PEG block at the central PLA core has been obtaine
d in order to compare the members of the particle series. It has been shown
that the surface area available to each PEG block decreases and then incre
ases throughout the PLA:PEG series. (C) 2000 Elsevier Science B.V. All righ
ts reserved.