Equine central nervous system (CNS) lymphoma can cause various clinical sig
ns. Although diagnosis of CNS lymphoma is rarely achieved antemortem, a hig
h degree of clinical suspicion may be reached by cerebrospinal fluid analys
is. All reported cases describe spinal cord involvement, but other areas of
the nervous system may be infiltrated with lymphoma as well. Prognosis for
horses with CNS lymphoma is grave because clinical deterioration often occ
urs rapidly. and successful treatment has not been reported.