Peptide inhibitors expressed in vivo

Peptide inhibitors isolated from libraries either through genetic screens o r binding assays have gained visibility in the past year especially with th e publication of four studies in model systems (two in Least, two in Escher ichia coli). These and other studies demonstrate that forward and reverse g enetic experiments with peptides can be extremely efficient in validating c andidate drug targets and in defining elements of biochemical pathways.