Hypopigmented mycosis fungoides: A report of 7 cases and review of the literature

Over the last 2 decades, hypopigmented macules have been reported with incr easing frequency as an initial presentation of mycosis fungoides (MF). We r etrospectively reviewed 7 patients with hypopigmented MF: The mean age was 35 years at disease onset, with a mean of 5.5 years' duration of illness be fore presentation. Ail of our patients were Fitzpatrick skin type IV or V, and most reported pruritus. Histologic findings in all cases were consisten t with MF: Treatment with topical nitrogen mustard produced repigmentation in 4 of 6 patients.