Although prohibited by law, fish poison plants are still widely used by ind
igenous tribes in Guyana. The latest ethnobotanical collections date from t
he first half of the 20th century and, from recent anthropological studies,
it cannot be deduced whether the same species are still used today. The pr
esent study attempts to clarify the taxonomy and ethnobotany of the fish po
isons, in particular those containing rotenone, currently used by Amerindia
ns in northwest Guyana. Specimens were collected from II species known to b
e ichthyotoxic, both from wild and cultivated sources. It was found that fi
sh poisons not only serve as a quick method of providing providing food irt
times of shortage, but also play an important role in magic rituals and tr
aditional medicine. Particular ly striking was the use of Lonchocarpus spp.
and Tephrosia sinapou in the treatment of cancer and AIDS. Further ethnobo
tanical and pharmacological research should focus on the medicinal applicat
ions of rotenone-yielding plants.