We sequenced a 173-nucleotide fragment of the small double-stranded virusli
ke RNA of Cryptosporidium parvum isolates from 23 calves and 38 humans. Seq
uence diversity was detected at 17 sites. Isolates from the same outbreak h
ad identical double-stranded RNA sequences, suggesting that this technique
may be useful for tracking Cryptosporidium infection sources.