The conformational behaviour of fucosyl and carbafucosyl mimetics in the free and in the protein-bound states

Authors
Carpintero, N Fernandez-Mayoralas, A Jimenez-Barbero, J
Citation
N. Carpintero et al., The conformational behaviour of fucosyl and carbafucosyl mimetics in the free and in the protein-bound states, EUR J ORG C, (4), 2001, pp. 681-689
Citations number
56
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
4
Year of publication
2001
Pages
681 - 689
Database
ISI
SICI code
1434-193X(200102):4<681:TCBOFA>2.0.ZU;2-3
Abstract
The conformational behaviours of fucosyl glycosides bearing a glyceryl agly con and their corresponding carbafucosyl glycomimetics have been studied bo th in aqueous solution and when bound to a fucose-specific lectin (Aurelia Aurantia Agglutinnin), using a combination of NMR spectroscopy (J and NOE d ata) and molecular mechanics calculations. Analogies and differences betwee n the mimetics and the natural compounds have been found.