Cerebral oedema in enuretic children during low-dose desmopressin treatment: a preventable complication

Seven cases of cerebral oedema have been observed in enuretic children duri ng low-dose desmopressin (DDAVP) treatment given in a dose of 7-21 mug dail y in the Czech Republic between 1995 and 1999, after the drug started to be marketed for this indication and delivered in simple bottles with a droppe r. All seven children (age 5-11 years, four boys) experienced a period of u nconsciousness but all recovered without sequelae, In most cases, safety me asures were underestimated and natraemia was not regularly controlled. Two children developed cerebral oedema after excessive water intake in preparat ion for uroflowmetry, another one drank much during a hot summer day, in on e diabetes insipidus was not recognised and two children were clearly non-c ompliant with reduced fluid intake on a long-term basis. Only in one child, no risk factor was found. Conclusion Proper selection and instruction of patients is needed to avert cerebral oedema during treatment with desmopressin for nocturnal enuresis.