Simultaneous occurrence of the haemolytic uraemic syndrome and acute post-infectious glomerulonephritis

We report on two children, a 12-year-old boy and a 6-year-old girl, with si multaneous occurrence of clinical and laboratory features consistent with b oth diarrhoea-negative haemolytic uraemic syndrome (D-HUS) and acute post-i nfectious glomerulonephritis (APGN). Both presented with acute renal insuff iciency, hypertension and oedema. Laboratory evaluation revealed micro-angi opathic anaemia with burr cells, thrombocytopenia, elevated lactic dehydrog enase and low complement C3. Urinalysis showed marked proteinuria and haema turia. Renal biopsy was characteristic of APGN, but not of HUS. The outcome was good in both children. Conclusion The simultaneous occurrence of diarrhoea-negative haemolytic ura emic syndrome and acute post-infectious glomerulonephritis is rare. The out come is generally good as is expected in the latter condition in contrast t o the former.