Sodium/iodide symporter (NIS) and cytokines

Citation
Pm. Schumm-draeger, Sodium/iodide symporter (NIS) and cytokines, EXP CL E D, 109(1), 2001, pp. 32-34
Citations number
35
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
ISSN journal
09477349 → ACNP
Volume
109
Issue
1
Year of publication
2001
Pages
32 - 34
Database
ISI
SICI code
0947-7349(2001)109:1<32:SS(AC>2.0.ZU;2-U
Abstract
It has been shown that TSH upregulates rat NIS gene expression in vitro, an d this induction can be modulated by cytokines. Analysis of the distributio n of rat NIS mRNA ex vivo demonstrated variable levels of NIS transcription in different tissue samples. - IL-1 beta and IL-6 have been found to decre ase NIS mRNA expression in TSH-stimulated FRTL-5-cells. IL-6 has no effect on NIS functional activity, whereas IL-1 beta suppresses iodide accumulatio n. The NIS is expressed in thyroid tissue of patients with autoimmune thyro id diseases, and its expression is increased in Graves' disease. With respe ct to other thyroidal autoantigens such as TPO and Tg, NIS obviously shows a very similar pattern to the well-described antigenic targets and may part icipate as an autoantigen in these diseases. - Up to now only data of in vi tro studies are available which started to evaluate the effects of differen t cytokines on NIS expression. The mechanisms of NIS regulation with respec t to cytokine modulation in thyroid autoimmune disease remain still unprove n and data of experimental in vivo studies and clinical trials in patients with thyroid autoimmune disease have to further elucidate these open questi ons in the future.