INCLUSION COMPLEXATION OF FENOFIBRATE WITH BETA-CYCLODEXTRIN AND HYDROXYPROPYL-BETA-CYCLODEXTRIN EVALUATION OF INTERACTIONS IN SOLUTION ANDSOLID COMPLEX CHARACTERIZATION

Interactions between fenofibrate and beta-cyclodextrin or hydroxypropy l-beta-cyclodextrin, as well as the possibility of obtaining inclusion complexes, were evaluated by several methods: a phase solubility diag ram, high-power liquid chromatography, differential scanning calorimet ry and X-ray diffractometry. Solid inclusion complexes were prepared b y spray-drying, kneading and solid dispersion. The dissolution profile s of the obtained powders were studied in order to define the most app ropriate cyclodextrin, preparation method and molar ratio to use in th e production of a fenofibrate inclusion complex. Finally, tablets were prepared with the powder of the complex and characterized by dissolut ion studies.