Pressure-assisted cold unfolding of proteins and its effects on the conformational stability compared to pressure and heat unfolding

Authors
Meersman, F Smeller, L Heremans, K
Citation
F. Meersman et al., Pressure-assisted cold unfolding of proteins and its effects on the conformational stability compared to pressure and heat unfolding, HIGH PR RES, 19(1-6), 2000, pp. 653-658
Citations number
11
Categorie Soggetti
Physics
Journal title
HIGH PRESSURE RESEARCH
ISSN journal
08957959 → ACNP
Volume
19
Issue
1-6
Year of publication
2000
Part
2
Pages
653 - 658
Database
ISI
SICI code
0895-7959(2000)19:1-6<653:PCUOPA>2.0.ZU;2-#
Abstract
The pressure-assisted cold unfolding of metmyoglobin was investigated and t he cold unfolded state was compared to the heat and pressure unfolded state s. Conformationally and mechanistically the pressure and cold unfolding pro cesses are found to be very alike, while the heat unfolding shows some pron ounced differences. We also propose a hypothesis on protein aggregation.