Regulation of matrix metalloproteinase expression in endothelial cells by heat-inactivated Streptococcus pneumoniae

Authors
Michel, U Zobotke, R Mader, M Nau, R
Citation
U. Michel et al., Regulation of matrix metalloproteinase expression in endothelial cells by heat-inactivated Streptococcus pneumoniae, INFEC IMMUN, 69(3), 2001, pp. 1914-1916
Citations number
26
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
3
Year of publication
2001
Pages
1914 - 1916
Database
ISI
SICI code
0019-9567(200103)69:3<1914:ROMMEI>2.0.ZU;2-7
Abstract
Matrix metalloproteinases (MMPs) may contribute to an impaired endothelial layer in several diseases. We examined the effect of heat-inactivated Strep tococcus pneumoniae R6 on MMP-2 and MMP-9 release by cultured aortic and br ain capillary endothelial cells. Treatment with heat-inactivated S. pneumon iae caused an increased release of MMP-2 by both cell types.