Objective: A great degree of controversy prevails over the existing reports
on the severity and outcome of acute viral hepatitis (AVH) during pregnanc
y. The present study describes the outcome of AVH associated with pregnancy
. A correlation was also assessed for gestation period, viral etiology and
outcome of AVH. Method: The serum samples of 273 females with viral hepatit
is (age group 18-23 years) were included in the study. Among them, 127 fema
les were pregnant and 146 were non-pregnant cases (as a control group). The
sera were screened for seromarkers of the hepatitis A virus (HAV) through
to the hepatitis E virus (HEV) by the latest available generation ELISA kit
s. Among the 127 pregnant females, 83 were AVH cases, while 44 were fulmina
nt hepatic failure (FHF) cases. Among the 146 non-pregnant females, 129 wer
e AVH and 17 were FHF cases. Result: Among the AVH pregnant females, 73 (57
.5%) had HEV infection. Fifty-eight percent of the HEV infected pregnant fe
males were associated with FHF. Among non-pregnant females HEV was document
ed in 67 (46%) cases. HBV infection was observed in 19% and 18% of the preg
nant and non-pregnant females, respectively. Twenty percent of the pregnant
and 33% of the non-pregnant females remained non-reactive for seromarkers
of HAV-HEV. The mortality rate was highest (56%) among HEV infected FHF cas
es during third trimester of pregnancy. The chi (2) test was applied to che
ck the statistical significance for the differences over the prevalence in
various groups. Conclusion: In the present study, HEV was found to be the c
hief etiological agent, associated with higher morbidity and mortality. How
ever, the incidence of HEV in pregnant females was not significantly differ
ent from non-pregnant females. The prevalence of HAV, HCV and HDV were very
low in the study. An increased incidence of FHF was noted among HEV infect
ed pregnant females, while infection with an agent other than A-E was commo
nly associated with FHF among non-pregnant females. (C) 2001 International
Federation of Gynecology and Obstetrics. Al rights reserved.