Improvement in the immunological and virological profile of HIV-infected po
pulation during the era of highly active antiretroviral therapy (HAART), ha
s allowed guidelines on discontinuation of Pneumocystis carinii pneumonia (
PCP) prophylaxis to be published. A case of a 37-year-old homosexual man, w
ho had sustained CD4 count over 200 cells/mul for 2 years while on secondar
y prophylaxis for PCP, who then developed PCP after cessation of prophylaxi
s, is presented. This case emphasizes the need for close monitoring of pati
ents who discontinued secondary PCP prophylaxis with respiratory symptoms.