Health care providers and payers are being asked to weigh data on the econo
mic impact of new interventions along with clinical evidence when making de
cisions about the care of patients, The notion of incorporating formal heal
th economic assessments into clinical and resource decisions is a difficult
concept for many in the health fare sector. However, it is the reality in
today's environment. To effectively participate in these ongoing discussion
s, clinicians and other decision makers must be able to understand and crit
ically assess the evidence on economic impact of medical interventions. Thi
s second of 2 articles describes the elements of comparative economic evalu
ations, reviewing the published literature on asthma and rhinitis in an att
empt to critically appraise the studies from the perspective of one who mig
ht use data for decision making. Unfortunately, the quality of the economic
evidence in these two disease states is not extensive, Until better econom
ic analyses are conducted and made available, the allocation of resources f
or asthma and allergic rhinitis will continue to primarily rely on expert o
pinion rather than evidence-based literature.