Effects of perfluorochemical distribution and elimination dynamics on cardiopulmonary function

Based on a physicochemical property profile, we tested the hypothesis that different perfluorochemical (PFC) liquids may have distinct effects on intr apulmonary PFC distribution, lung function, and PFC elimination kinetics du ring partial liquid ventilation (PLV). Young rabbits were studied in five g roups [healthy, PLV with perflubron (PFB) or with perfluorodecalin (DEC); s aline lavage injury and conventional mechanical ventilation (CMV); saline l avage injury PLV with PFB or with DEC]. Arterial blood chemistry, respirato ry compliance (Cr), quantitative computed tomography of PFC distribution, a nd PFC loss rate were assessed for 4 h. Initial distribution of PFB was mor e homogenous than that of DEC; over time, PFB redistributed to dependent re gions whereas DEC distribution was relatively constant. PFC loss rate decre ased over time in all groups, was higher with DEC than PFB, and was lower w ith injury. In healthy animals, arterial P-O2 (Pa-O2) and Cr decreased with either PFC the decrease was greater and sustained with DEC. Lavaged animal s treated with either PFC demonstrated increased Pa-O2, which was sustained with PFB but deteriorated with DEC. Lavaged animals treated with PFB demon strated increased Cr, higher Pa-O2, and lower arterial P-CO2 than with CMV or PLV with DEC. The results indicate that 1) initial distribution and subs equent intrapulmonary redistribution of PFC are related to PFC properties; 2) PFC distribution influences PFC elimination, gas exchange, and Cr; and 3 ) PFC elimination, gas exchange, and Cr are influenced by PFC properties an d lung condition.