Substrate utilization during exercise with glucose and glucose plus fructose ingestion in boys ages 10-14 yr

We measured substrate utilization during exercise performed with water (W), exogenous glucose (G), and exogenous fructose plus glucose (FG) ingestion in boys age 10-14 yr. Subjects (n = 12) cycled for 90 min at 55% maximal O- 2 uptake while ingesting either W (25 ml/kg), 6% G (1.5 g/kg), or 3% F plus 3% G (1.5 g/kg). Fat oxidation increased during exercise in all trials but was higher in the W (0.28 +/- 0.023 g/min) than in the G (0.24 +/- 0.023 g /min) and FG (0.25 +/- 0.029 g/min) trials (P = 0.04). Conversely, total ca rbohydrate (CHO) oxidation decreased in all trials and was lower in the W ( 0.63 +/- 0.05 g/min) than in the G (0.78 +/- 0.051 g/min) and FG (0.74 +/- 0.056 g/min) trials (P = 0.009). Exogenous CHO oxidation, as determined by expired (CO2)-C-13, reached a maximum of 0.36 +/- 0.032 and 0.31 +/- 0.030 g/min at 90 min in G and FG, respectively (P = 0.04). Plasma insulin levels decrease during exercise in all trials but were twofold higher in G than i n W and FG (P < 0.001). Plasma glucose levels decreased transiently after t he onset of exercise in all trials and then returned to preexercise values in the W and FG (<similar to>4.5 mmol/l) trials but were elevated by simila r to1.0 mmoYI in the G trial (P < 0.001). Plasma lactate concentrations dec reased after the onset of exercise in all trials but were lower by -0.5 mmo l/l in W than in G and FG (P = 0.02). Thus, in boys exercising at a moderat e intensity, the oxidation rate of G plus F is slightly less than G alone, but both spare endogenous CHO and fat to a similar extent. In addition, com pared with flavored W, the ingestion of G alone and of G plus F delays exha ustion at 90% peak power by <similar to>25 and 40%, respectively, after 90 min of moderate-intensity exercise.