Plasticity in skeletal, cardiac, and smooth muscle - Invited review: Plasticity and energetic demands of contraction in skeletal and cardiac muscle

Invited Review: Plasticity and energetic demands of contraction in skeletal and cardiac muscle. J Appl Physiol 90: 1158-1164, 2001.-Numerous studies h ave explored the energetic properties of skeletal and cardiac muscle fibers . In this mini-review, we specifically explore the interactions between act in and myosin during cross-bridge cycling and provide a conceptual framewor k for the chemomechanical transduction that drives muscle fiber energetic d emands. Because the myosin heavy chain (MHC) is the site of ATP hydrolysis and actin binding, we focus on the mechanical and energetic properties of d ifferent MHC isoforms. Based on the conceptual framework that is provided, we discuss possible sites where muscle remodeling may impact the energetic demands of contraction in skeletal and cardiac muscle.