Comparative safety of bone remodeling agents with a focus on osteoporosis therapies

This article reviews the different treatments currently available for osteo porosis and examines the benefits and adverse events that are associated wi th each. While emphasizing safety considerations, this review summarizes th e following treatments for osteoporosis: calcium supplements, fluoride, hor mone replacement therapy, raloxifene, bisphosphonates, salmon calcitonin, a nd calcitriol. Before prescribing any of these agents, the clinician should review the risk/benefit profile of each drug in the context of the individ ual patient's history, concomitant diseases, concurrent medications, and ge neral physical condition. Journal of Clinical Pharmacology, 2001;41:239-250 (C) 2001 the American College of Clinical Pharmacalogy.