Antidepressant-associated mania and psychosis resulting in psychiatric admissions

Background: The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increas e in antidepressant use. These changes raise concern as to the likelihood o f a corresponding increase in adverse behavioral reactions attributable to these drugs. Method: All admissions to a university-based general hospital psychiatric u nit during a 14-month period were reviewed. Results: Forty-three (8.1%) of 533 patients were found to have been admitte d owing to antidepressant-associated mania or psychosis. Conclusion: Despite the positive changes in the side effect profile of anti depressant drugs, the rate of admissions due to antidepressant-associated a dverse behavioral effects remains significant.