This article outlines the up-to-date understanding of the molecular basis o
f primary ventricular arrhythmias. Two disorders have recently been well de
scribed at the molecular level, the long QT syndromes and Brugada syndrome,
and this article reviews the current scientific knowledge of each disease.
A third disorder, arrhythmogenic right ventricular dysplasia, which is on
thc cusp of understanding, will also be described.