Synthesis of [phenyl-2-H-3]-travoprost: Isopropyl ester prodrug of a selective prostaglandin FP receptor agonist

Authors
Selliah, R Dantanarayana, A Haggard, K Egan, J Do, EU May, JA
Citation
R. Selliah et al., Synthesis of [phenyl-2-H-3]-travoprost: Isopropyl ester prodrug of a selective prostaglandin FP receptor agonist, J LABEL C R, 44(3), 2001, pp. 173-183
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
44
Issue
3
Year of publication
2001
Pages
173 - 183
Database
ISI
SICI code
0362-4803(20010315)44:3<173:SO[IEP>2.0.ZU;2-0
Abstract
A method for the preparation of tritium labeled travoprost, a new ocular hy potensive prostaglandin, is described. A highly selective catalytic deiodin ation has been identified which provides [phenyl-2-H-3]-travoprost in a sin gle synthetic step from 2'-iodo-travoprost.