Citation
Ht. Ravert et al., Radiosynthesis of a ligand for studying the glycine transporter: [C-11]ALX-5407, J LABEL C R, 44(3), 2001, pp. 241-246
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803
→ ACNP
Volume
44
Issue
3
Year of publication
2001
Pages
241 - 246
Database
ISI
SICI code
0362-4803(20010315)44:3<241:ROALFS>2.0.ZU;2-J
Abstract
[C-11]ALX-5407, R-N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl] sarcosi
ne, a chiral glycine transporter 1 antagonist, was labeled with [C-11]iodom
ethane by N-alkylation of methyl ester protected N-normethyl precursor, ALX
-5536, and subsequent saponification of the methyl ester protecting group.
The time for synthesis, purification, and formulation was 33 minutes with a
n average specific radioactivity of 3909 mCi/mu mol (EOS) and average decay
corrected radiochemical yield of 8%.