The relation between acute physiological variables and outcome on the Glasgow outcome scale and disability rating scale following severe traumatic brain injury

The relation between outcome and duration of adverse physiological events w as studied, using suggested critical physiological values, Subjects were 18 4 patients with severe traumatic brain injury who received continuous monit oring of intracranial pressure (ICP), mean arterial pressure (MAP), cerebra l perfusion pressure (CPP), and jugular venous oxygen satuation, Longer dur ations of adverse physiological events were significantly related to Glasgo w Outcome Scale (GOS) scores and Disability Rating Scale (DRS) scores for a ll variables at all timepoints postinjury, When analyses excluded patients who died, the relation between adverse physiological events and GOS was non significant; however, duration of ICP, MAP, and CPP still accounted for a s ignificant portion of the variance in DRS scalres, The relative sensitivity of the GOS and DRS is discussed.