Late results of heart valve replacement with the Hancock II bioprosthesis

Citation
Te. David et al., Late results of heart valve replacement with the Hancock II bioprosthesis, J THOR SURG, 121(2), 2001, pp. 268-278
Citations number
18
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
ISSN journal
00225223 → ACNP
Volume
121
Issue
2
Year of publication
2001
Pages
268 - 278
Database
ISI
SICI code
0022-5223(200102)121:2<268:LROHVR>2.0.ZU;2-Y
Abstract
Objective: To review the late clinical outcomes of patients who had isolate d aortic or mitral valve replacement with the Hancock II bioprosthesis. Methods: From 1982 to 1994, 670 patients underwent isolated aortic valve re placement and 310 underwent isolated mitral valve replacement with the Hanc ock II bioprosthesis (Medtronic Inc, Minneapolis, Minn). Mean age was 65 +/ - 12 years in both groups. Most patients were in New York Heart Association functional classes III or IV, and concomitant coronary artery disease was present in 44% of patients in the aortic valve group and 41% of patients in the mitral valve group. Patients were followed up prospectively at periodi c intervals. Mean follow-up was 87 +/- 45 months in the aortic valve group and 83 +/- 50 months in the mitral valve group, and it was 99% complete. Results: Actuarial survival at 15 years was 47% +/- 3% in the aortic valve group and 30% +/- 5% in the mitral valve group. Older age, advanced functio nal class, impaired left ventricular function, active endocarditis, and cor onary artery disease were independent predictors of late death. The freedom from thromboembolic complications at 15 years was 83% +/- 3% in the aortic and 87% +/- 3% in the mitral valve group. The freedom from infective endoc arditis at 15 years was 96% +/- 1% in the aortic and 91% +/- 1% in the mitr al valve group. At 15 years, the actuarial and actual freedom from structur al valve deterioration was 81% +/- 5% and 90% +/- 3%, respectively, in the aortic group and 66% +/- 6% and 83% +/- 3%, respectively, in the mitral gro up. Younger age, mitral valve position, and poor ventricular function were independent predictors of structural valve deterioration. The freedom from repeat valve replacement at 15 years was 77% +/- 5% in the aortic group and 69% +/- 6% in the mitral. The vast majority of patients had functional imp rovement after valve replacement. Conclusions: The Hancock II bioprosthesis has provided good clinical outcom es and is a durable valve, particularly in the aortic position in older pat ients.