Objective: To review the late clinical outcomes of patients who had isolate
d aortic or mitral valve replacement with the Hancock II bioprosthesis.
Methods: From 1982 to 1994, 670 patients underwent isolated aortic valve re
placement and 310 underwent isolated mitral valve replacement with the Hanc
ock II bioprosthesis (Medtronic Inc, Minneapolis, Minn). Mean age was 65 +/
- 12 years in both groups. Most patients were in New York Heart Association
functional classes III or IV, and concomitant coronary artery disease was
present in 44% of patients in the aortic valve group and 41% of patients in
the mitral valve group. Patients were followed up prospectively at periodi
c intervals. Mean follow-up was 87 +/- 45 months in the aortic valve group
and 83 +/- 50 months in the mitral valve group, and it was 99% complete.
Results: Actuarial survival at 15 years was 47% +/- 3% in the aortic valve
group and 30% +/- 5% in the mitral valve group. Older age, advanced functio
nal class, impaired left ventricular function, active endocarditis, and cor
onary artery disease were independent predictors of late death. The freedom
from thromboembolic complications at 15 years was 83% +/- 3% in the aortic
and 87% +/- 3% in the mitral valve group. The freedom from infective endoc
arditis at 15 years was 96% +/- 1% in the aortic and 91% +/- 1% in the mitr
al valve group. At 15 years, the actuarial and actual freedom from structur
al valve deterioration was 81% +/- 5% and 90% +/- 3%, respectively, in the
aortic group and 66% +/- 6% and 83% +/- 3%, respectively, in the mitral gro
up. Younger age, mitral valve position, and poor ventricular function were
independent predictors of structural valve deterioration. The freedom from
repeat valve replacement at 15 years was 77% +/- 5% in the aortic group and
69% +/- 6% in the mitral. The vast majority of patients had functional imp
rovement after valve replacement.
Conclusions: The Hancock II bioprosthesis has provided good clinical outcom
es and is a durable valve, particularly in the aortic position in older pat
ients.