Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines

Authors
Britton, WJ Martin, E Kamath, AT Neupane, KD Roche, PW
Citation
Wj. Britton et al., Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines, LEPROSY REV, 71, 2000, pp. S176-S181
Citations number
17
Categorie Soggetti
Dermatology
Journal title
LEPROSY REVIEW
ISSN journal
03057518 → ACNP
Volume
71
Year of publication
2000
Supplement
S
Pages
S176 - S181
Database
ISI
SICI code
0305-7518(200012)71:<S176:IAMLIW>2.0.ZU;2-J
Abstract
We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and th e immunodominant 35 kDa protein of M, leprae as the candidate antigen. A DN A vaccine that expresses the M. leprae 35 kDa protein both stimulated inter feron-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protect ion against M. leprae-infection of mice.